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| Areas of Expertise |
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| Projects |
| Computing Resources |
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| Dr. Ranajit Chakraborty' Areas of Expertises
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Population Genetics in the context of complex diseases
Relative roles of evolutionary factors affecting genetic structure of populations and
how they relate to underlying genetic variability at gene loci underlying complex diseases
Molecular Evolution
Statistical analysis of molecular data, including bi- and multi-
allelic markers, nuclear as well as lineage specific sequence data; roles of different
mutational processes in drawing inference regarding genome diversity; detecting
signatures of natural selection; estimation of coalescence time of mutations affecting
diseases
Genetics of Admixed Populations
Developer of novel methods of admixture
estimation at group and individual level; utility of population-specific markers in
mapping genes for complex diseases
Statistical Genetics:
Relative efficiencies of sampling design for gene mapping;
Development of new sampling designs of gene mapping that incorporates effects of
population heterogeneity as well as "selective" sampling of individuals
Cancer Epidemiology:
Developer of measures of familial aggregation of cancers;
cancer risk evaluation incorporating effects of genetic heterogeneity in cancer-
susceptibility; effect of radiation and chemical exposure on cancer susceptibility;
cost-benefit analysis of screening modalities
Quantitative Genetics:
Inter-relationships between various measures of risk for
quantitative phenotypes; risk estimation for multifactorial traits; evaluation of
environmental risk factors for multifactorial diseases
Health Informatics:
Health of migrant populations; biosocial behavior and health
behaviors and their impact on chronic disease risks
DNA Forensics:
Use of DNA markers in forensic identification and establishing
relationships; use of DNA markers in mass disaster cases; developer of efficient
battery of DNA markers as well as computer software for user-friendly applications
of population genetic principles in DNA data bases maintained by the Criminal
Justice System of the US Government; Internationally sought DNA expert
Sampling Design for Genealogical studies of Complex Diseases:
Record linking, construction of genealogies; nonparametric methods of familial risk;
selection techniques for detecting informative families for linkage/segregation analyses.
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